ADAMTS13: AN EMERGING TARGET IN STROKE THERAPY

ADAMTS13: An Emerging Target in Stroke Therapy

Thrombosis is the predominant underlying mechanism of acute ischemic stroke (AIS).Though thrombolysis with R/C Helicopter tPA has been proven to be effective in treating AIS within the time window, the majority of AIS patients fail to receive tPA due to various reasons.Current medical therapies for AIS have limited efficacy and pose a risk of intra

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Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors

Bacterial infections, particularly hospital-acquired infections caused by Pseudomonas aeruginosa, have become a global threat with a high mortality rate.Gram-negative bacteria including P.aeruginosa R/C Helicopter employ N-acyl homoserine lactones (AHLs) as chemical signals to regulate the expression of pathogenic phenotypes through a mechanism cal

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